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The Gut Microbiome-Heart Connection

Dr. Judy Magalhaes

How Your Gut Microbiome Influences Cardiovascular Health


Did you know your gut health has a direct impact on your heart? ❤️


Emerging research shows that your gut microbiome does more than aid digestion, it also plays a large role in heart health!



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A balanced gut can support healthy cholesterol levels, reduce inflammation, and even lower the risk of heart disease.


Taking care of your gut means taking care of your heart!


Gut Dysbiosis and Cardiovascular Diseases


Cardiovascular disease (CVD) includes conditions that affect the heart and blood vessels, such as coronary artery disease, stroke, heart failure, and arrhythmias.

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Dysbiosis, an imbalance in gut bacteria, has a significant impact on overall health, including cardiovascular well-being.


Many studies have shown the role of dysbiosis in CVD, linking it to conditions such as:



Serotonin’s Role in Heart Health


Your gut bacteria produce essential neurotransmitters like serotonin, GABA, dopamine, norepinephrine, and melatonin.


While serotonin is usually known as the "happy hormone", it also helps regulate energy levels, digestion, and cardiovascular function. Serotonin influences heart function in several ways:



The Gut Microbiome and Cholesterol

Recent research suggests that certain gut bacteria may play a big role in cholesterol levels and overall risk of cardiovascular disease.


One interesting discovery is the role of Oscillibacter in cholesterol metabolism.


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Studies have shown that higher levels of Oscillibacter in the gut are associated with:


  • Lower cholesterol levels

  • Lower triglycerides

  • Lower blood glucose

  • Higher HDL (“good” cholesterol) levels




The Impact of Trimethylamine-N-Oxide (TMAO)


An imbalance in gut bacteria can lead to the production of harmful metabolites, such as trimethylamine-N-oxide (TMAO), which has been shown to:


  • Alter cholesterol metabolism

  • Promote inflammation

  • Impair endothelial function

  • Increase clot formation through platelet activation


Strategies such as dietary interventions, prebiotics, and probiotics have shown promise in reducing TMAO levels and mitigating its adverse cardiovascular effects.



Functional Medicine Approach to The Gut Microbiome and Heart Connection


As we learn more about the gut-heart connection, it’s clear that a healthy microbiome plays a big role in heart health.


Targeting gut imbalances like dysbiosis could help manage cardiovascular risk factors- something traditional treatments often miss.


If you have high cholesterol or heart disease, checking your gut health might be a game-changer.


Remember, your microbiome could be the key to a healthier heart!




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Additional Resources


  1. https://pubmed.ncbi.nlm.nih.gov/32762536/

  2. https://pubmed.ncbi.nlm.nih.gov/33079568/

  3. https://pubmed.ncbi.nlm.nih.gov/33537709/

  4. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8995494/

  5. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9773315/

  6. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8368126/

  7. https://pubmed.ncbi.nlm.nih.gov/31043907/

  8. https://pubmed.ncbi.nlm.nih.gov/31460832/

  9. https://pubmed.ncbi.nlm.nih.gov/32323183/

  10. https://pmc.ncbi.nlm.nih.gov/articles/PMC8322927/

  11. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8322927/

  12. https://pubmed.ncbi.nlm.nih.gov/30458552/

  13. https://pubmed.ncbi.nlm.nih.gov/33642219/

  14. https://pubmed.ncbi.nlm.nih.gov/38627565/

  15. https://pubmed.ncbi.nlm.nih.gov/33537709/

  16. https://www.nih.gov/news-events/nih-research-matters/gut-bacteria-may-reduce-cholesterol-lower-heart-disease-risk

  17. https://pubmed.ncbi.nlm.nih.gov/28360349/

  18. https://pubmed.ncbi.nlm.nih.gov/36768264/

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